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It also appears unlikely that a single dose will provide lifelong immunity, with data suggesting that immunity lasts only 12–18 months. The most recent data suggests that the vaccine effectively protects the elderly – a particularly vulnerable and high-priority group – with 94% efficacy in people aged over 65 years old. The duration that the vaccine provides immunity is unknown, thus complicating decision-makers’ abilities to gauge vaccine dosing, timing, budgeting, and possibly increasing the risk of an inequitable distribution. The vaccine’s efficacy may still change following further studies, or its effectiveness may wane over time. Public concerns about the longer-term safety of the vaccine remain valid, considering that it may take months or years for these effects to become evident. Furthermore, although Pfizer reported no significant safety concerns to date, the medium- and long-term safety of the vaccine remain unknown.
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Whilst this is a significant breakthrough, it remains a relatively small sample and a short time horizon. Phase III trials of the vaccine involving 43,538 participants produced 170 confirmed cases of COVID-19 in the first 28 days, with the vaccine found to be 95% effective in preventing COVID-19 (162 cases observed in the control group versus eight in the vaccinated group).
WHEN DID PFIZER ANNOUNCE VACCINE TRIAL
ģ. Issues with the data of the vaccine trial Yet, are such thoughts premature? Is it naïve to think that an effective vaccine is the solution to the pandemic? Despite the optimism surrounding a vaccine, many challenges exist, from guaranteeing its safety and efficacy, to mass production and distribution, to challenges with public messaging, particularly with rising vaccine hesitancy in high-income nations. In response, stock markets rallied and hope spread worldwide, as the prospect of a return to normality became a tantalising possibility. However, the confidence rose further with new data, published on November 18, 2020, revealing their vaccine now appears to be 95% effective.
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According to interim results published on November 9, 2020, the vaccine appeared 90% effective. Although over 40 vaccine candidates now exist, Pfizer and BioNTech’s vaccine generated the most excitement as it was the first to reveal promising efficacy data. The recent news of Pfizer and BioNTech’s COVID-19 vaccine gave the world a sense of light at the end of a tunnel.